Treatment may vary depending on the type and severity of the disorder, as well as response to previous therapy and other medications the person may be taking. The most commonly used treatments for von Willebrand disease include:
DDAVP® – Desmopressin acetate is used to treat some types of von Willebrand Disease. DDAVP is usually effective in people with Type 1 and some subtypes of Type 2. The medication can be sprayed into the nose or injected into the blood stream. This is a syntheic hormone that stimulates the body to release more von Willebrand stored in the lining of the blood vessels.
Factor Concentrates with von Willebrand Factor – Factor concentrates are used to treat people with Type 2b and Type 3. It is also used for people with Type 2A prior to surgery or if they are experiencing severe bleeding. The brands that contain VWF include: Alphanate SD®, Humate P®, Koate DVI®, and Wilate®.
Contraceptives – Estrogen hormones can boost levels of VWF and factor VIII activity and therefore can help control heavy menstrual cycles. Other contraceptive devices placed in the uterus can also help reduce heavy bleeding during menstruation.
Anti-fibrinolytic or clot-stabilizing medications. These medications are usually prescribed before or after surgical procedures. Aminocaproic acid (Amicar) and tranexamic acid (Cyklokapron) can slow down the breakdown of clotting factors and therefore can help keep a clot in place once it has formed.