Page 12 - HFA_Dateline_2019_Q1_Spring_SpecialEdition

Current Products | Factor VIII

VIII Recombinant Clotting Factor

Manufacturer Product Type Half Life
Bayer Jivi PEGylated Recombinant Clotting Factor
Bayer Kogenate FS Recombinant Clotting Factor 17.9 hours
Bayer Kovaltry Recombinant Clotting Factor
13 hours

0 to <6 yrs : 12 hours
6 to <12 yrs: 12 hours
12 to 17 yrs: 14 hours
≥18 yrs: 14 hours

Bioverativ Eloctate Recombinant Clotting Factor 19.7 hours (17.4, 22.0) in adults
Pediatric:
CSL Behring Afstyla Recombinant Clotting Factor 12 to 17 years: 16.4 hours (14.1, 18.6)
6 to 11 years: 14.9 hours (12.0, 17.8)
CSL Behring Helixate FS* Recombinant Clotting Factor 1 to 5 years: 12.7 hours (11.2, 14.1)
Recombinant Clotting Factor
Novo Nordisk Novoeight After single dose of 50 IU/kg:
Adults (≥18 years): 14.2 hours (mean);
Octapharma Nuwiq Antihemophilic Recombinant Adolescents (≥12 to <18 years): 14.3 hours (mean);
Clotting Factor Children: (0 to <6 yrs): 10.4 hours (mean);
(≥6 to <12 years): 10.2 hours (mean)

Adults: 13.7-14.6 hours (mean)
Children: 10.7 hours (mean)

Adults/adolescents:
One Stage Clotting Assay
• 10.8 hours
Chromogenic Assay
• 12.0 hours
Pediatrics:
One Stage Clotting Assay
• 0-<6 yo - 7.7 hours
• 6-<12 yo - 8.0 hours
Chromogenic Assay -
• 0-<6 yo - 10.0 hours
• 6-<12 yo - 9.4 hours

17.1 +/- 11.2hrs. (Adults); 13.1 +/- 2.6hrs.
(6-≤12 yrs.); 11.9 +/- 5.4hrs. (2-5 yrs.)

Pfizer Xyntha Recombinant Clotting Factor 11.2 ± 5.0 hoursa,b

Pfizer Xyntha/Xyntha Recombinant Clotting Factor 11.2 ± 5.0 hoursa,b
Solofuse

12 Dateline Federation | Special Issue 2018-19