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FACTOR REPLACEMENT REFLECTS THE
                       PROTECTION WITHIN

    References: 1. Peyvandi F, Garagiola I, Young G. The past and future           For people with hemophilia, Factor treatment temporarily
    of haemophilia: diagnosis, treatments, and its complications. Lancet.          replaces what’s missing.1 With a long track record of proven
    2016;388:187-197. 2. Wolberg AS. Plasma and cellular contributions             results, Factor treatment works with your body’s natural
    to fibrin network formation, structure and stability. Haemophilia.             blood clotting process to form a proper clot.2,3
    2010;16(suppl 3):7-12. 3. King MW. Introduction to blood coagulation.          Brought to you by Shire, dedicated to pursuing advancements
    http://themedicalbiochemistrypage.org/blood-coagulation.php. Last              in hemophilia for more than 60 years.
    modified January 2, 2017. Accessed November 21, 2016.
                                                                                   Stay empowered by the possibilities.
    ©2017 Shire US Inc., Lexington, MA 02421.
    All rights reserved. 1-800-828-2088.                                                                                                                                               5/8/17 7:08 AM
    Shire and the Shire Logo are registered trademarks of
    Shire Pharmaceutical Holdings Ireland Limited or its affiliates. S28150 01/17

   HEMP16CRCH0737_JA_7_5x4_625_JUNE_B&W.indd 1

   Talk to your doctor to see if
   ADYNOVATE may be right for you.

                                      For more information, please visit

                                www.ADYNOVATE.com

   ©2016 Shire US Inc., Lexington, MA 02421. All rights reserved. 1-800-828-2088.
   SHIRE and the Shire Logo are registered trademarks of Shire Pharmaceutical Holdings Ireland Limited or its affiliates.
   ADYNOVATE is a registered trademark of Baxalta Incorporated, a wholly owned, indirect subsidiary of Shire plc.
   S32930 06/17

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