If you have hemophilia C, you have a deficiency of FXI. Hemophilia C is usually hereditary and affects both genders equally. In rare cases, it can be acquired due to another disease state, such as lupus. After VWD, hemophilia A, and hemophilia B, it is the fourth most common bleeding disorder and is thought to affect 1 in 100,000 of the adult population. Unlike the other bleeding disorders, hemophilia C occurs more predominantly in one demographic: Jewish people of Ashkenazi (or Eastern European) descent, where it is estimated to affect 8% of the population.
Joint and muscle bleeds are not common with hemophilia C. Hemophilia C symptoms can vary and might not be related to your FXI level, and bleeds may occur after surgery, dental procedures, or trauma, but bleeding tendencies are unpredictable and inconsistent.
Hemophilia C is also called plasma thromboplastin antecedent deficiency, PTA deficiency, or Rosenthal syndrome. Hemophilia C can affect any demographic, but a higher number of individuals of Ashkenazi Jewish descent and the Basque population of Southern France are affected.